SULINDAC PLUS A PHOSPHOLIPID IS EFFECTIVE FOR POLYP REDUCTION AND SAFER THAN SULINDAC ALONE IN A MOUSE MODEL OF COLORECTAL CANCER DEVELOPMENT

Sulindac plus a phospholipid is effective for polyp reduction and safer than sulindac alone in a mouse model of colorectal cancer development

Abstract Background Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin and sulindac are effective for colorectal cancer prevention in humans and some animal models, but concerns over gastro-intestinal (GI) ulceration and bleeding limit their potential for chemopreventive use in broader populations.Recently, the combination of aspirin wi

read more


English Pauper Letters in the Eighteenth Century and Beyond

This article explores a new subtype of vernacular correspondence emerging in the early eighteenth century, the pauper letter, providing a textual classification of this new text type and an account of its variability and evolution into the nineteenth century.The study is based on 189 letters sent between 1730 and 1834 by the poor applying for suppo

read more

Modelling the Distribution of Forest-Dependent Species in Human-Dominated Landscapes: Patterns for the Pine Marten in Intensively Cultivated Lowlands.

In recent years, the "forest-specialist" pine marten Martes martes Quilts has been reported to also occur also in largely fragmented, lowland landscapes of north-western Italy.The colonization of such an apparently unsuitable area provided the opportunity for investigating pine marten ecological requirements and predicting its potential south- and

read more